2-(1-adamantyl)-4-chloro-5-[(4-fluorophenyl)methylamino]-3-pyridazinone

The compound 2-(1-adamantyl)-4-chloro-5-[(4-fluorophenyl)methylamino]-3-pyridazinone, also known as **BMS-986165**, is a potent and selective inhibitor of the enzyme **histone deacetylase 6 (HDAC6)**.

Here's why it's important for research:

**Histone Deacetylase 6 (HDAC6)**

* HDAC6 is an enzyme that plays a crucial role in regulating cellular processes like protein degradation, autophagy, and inflammation.
* It specifically deacetylates alpha-tubulin, a protein essential for microtubule formation, which affects cell structure and movement.

**BMS-986165 as an HDAC6 Inhibitor**

* BMS-986165 selectively inhibits HDAC6, meaning it targets this specific enzyme with high affinity and minimal effect on other HDACs.
* This selective inhibition allows researchers to study the specific functions of HDAC6 in various cellular processes.

**Research Applications of BMS-986165**

* **Cancer Research:** Inhibition of HDAC6 has been shown to have anti-cancer effects. BMS-986165 has been investigated for its potential in treating certain types of cancers, including multiple myeloma, leukemia, and solid tumors.
* **Neurological Disorders:** HDAC6 is involved in the regulation of neuronal function and its inhibition may have therapeutic potential for neurological conditions such as Alzheimer's disease and Parkinson's disease.
* **Inflammatory Diseases:** HDAC6 is implicated in inflammatory responses. BMS-986165 may be useful for studying and treating inflammatory disorders.
* **Other Applications:** Research using BMS-986165 has explored its potential in treating diseases related to skeletal muscle atrophy, fibrosis, and viral infections.

**In Summary**

BMS-986165, as a potent and selective HDAC6 inhibitor, is a valuable tool for researchers investigating the role of HDAC6 in various biological processes. Its potential in treating various diseases, including cancer, neurological disorders, and inflammatory conditions, makes it a promising therapeutic candidate.